POTENCI – ncIDP redefined


The follow-up to the ncIDP library of random coil chemical shifts.

POTENCI is parametrized using a large curated database of chemical shifts for protein segments with validated disorder (Intrinsically disordered proteins – IDPs – and intrinsically disordered regions – IDRs). It takes pH and temperature explicitly into account, and includes sequence-dependent nearest and next-nearest neighbor corrections as well as second-order corrections.

POTENCI is the most accurate random coil chemical shifts prediction method currently available.


Nielsen, J.T. & Mulder, F.A.A. J Biomol NMR (2018). https://doi.org/10.1007/s10858-018-0166-5


Click here to predict your random coil chemical shifts from sequence with POTENCI